eBooks (at least for now) have a lower resolution than paper, but offer the ability to introduce new interactive elements.
In terms of graphic design, I'm not sure there's a huge difference, though. It's still a book in concept--be it on paper or screen. You may want to look into some of the 'interactive' books being created that include music and animation and the like, though I question if those are still really 'ebooks'.
I think an analogy may be TV. Is the internet forever changing television? Of course it is. That said, a TV show is still a TV show, regardless if you watch it on your actual TV or your iPad.