That's handlettered for NYC subway (reproduced for placards).
Some similars: MVB Solano Gothic, MS Refrigerator Deluxe, RR Raleigh Gothic, FB Agency...

Thank for the help!

Thanks for the help!

Thanks for the help!

Thanks for the help!

sorry computer gone haywire!

Two things: I'd say the font looks more like a variation on Bank Gothic, http://en.wikipedia.org/wiki/Bank_Gothic.

And, a topic I'm even more interested in, the sign is unlikely to be from a subway line, because its two destinations do not match those of any familiar train from any era. It's most likely a placard from some forgotten streetcar route in Manhattan, perhaps across Midtown. "Hudson" could refer to Hudson Street rather than the river, in which case it would be for a streetcar or bus running across Greenwich Village, but that seems less likely to me, as 2nd Avenue is arbitrarily far west for an East Side streetcar terminus in the Village.

I don't have access to a good streetcar map from the '20s or '30s just now, but that's my guess.