What do you mean by 'line spacing'? That normally suggests interline spacing, i.e. leading, but your illustration shows only one line of text, so perhaps people are too confused to respond?
Okay so perhaps my terminology is incorrect. My apologies. I'm specifically speaking about the difference of the gaps between the very top where the blue starts and the cap-height compared to the baseline and where the blue ends (see red arrows).
Most capitals won't sit vertically centered in their space because that space is set up to accommodate descenders of the lowercase (and potentially Q and J). Maybe that accounts for what you're seeing.
That's what I initially figured. It's just incredibly difficult to set a line-height and it output equivalent space above and below. I was hoping to not have to result to padding or margins.
After God finished designers, he (she?) was heard to mutter "Another half-baked idea. Now I've got to make typesetters, or nothing will ever get done."